Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells.

OBJECTIVES:Tyrosine kinase inhibitor (TKI)-treated acute myeloid leukemia (AML) patients commonly show rapid and significant peripheral blood blast cell reduction, however a marginal decrease in bone marrow blasts.This suggests a protective environment and highlights the demand for a better understanding of stromal:leukemia cell communication.As a

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Analytical examination of alcohol-based hand disinfectants in our country and evaluation with respect to COVID-19 pandemic

INTRODUCTION: The use of alcohol-based hand disinfectants (ABHD) is recommended in the COVID-19 pandemic.In this study, it was aimed to analyze the content of ABEDs in our country and to discuss the findings in the light of literature.METHODS: ABHDs in our country were searched on Intakes the Google search engine.Content information of the commerci

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A competitive binding-mass spectrometry strategy for high-throughput evaluation of potential critical quality attributes of therapeutic monoclonal antibodies

Therapeutic monoclonal antibodies (mAbs) have a propensity to host a large number of chemical and enzymatical modifications that need to be properly assessed for their potential impact on target binding.Traditional strategies of assessing the criticality of these attributes often involve a laborious and low-throughput variant enrichment step prior

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Design issues in the production of hyper-books and visual-books

This paper describes an ongoing research project in the area of electronic books.After a brief overview of the state of the art in this field, two new forms of electronic book are presented: hyper-books and visual-books.A flexible environment allows them to be produced in a semi-automatic way starting from different sources: electronic texts (as in

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